Study: Atlas of Healthy and SHIV-Infected Non-Human Primate Lung and Ileum ACE2+ Cells 8308 cells
We used previously unpublished NHP (Macaca mulatta) lung and small intestinal ileal tissue collected following necropsy of healthy adult animals with profiled with Seq-Well v1 to assess which cell types tissues represent natural targets of SARS-CoV-2. We saw that epithelial cells express ACE2 or co-express ACE2 and TMPRSS2.
Note that this is a pre-publication dataset, so in this study we include expression of ACE2 and TMPRSS2 across all cells and expression of all genes in the ACE2+ subsets: epithelial cells of the lung and enterocytes in the ileum.
Contributors (listed alphabetically): Shaina L. Carroll, Lucrezia Colonna, Leslie S. Kean, Alex K. Shalek, Alison Yu, Hengqui Betty Zheng, Carly G. K. Ziegler