Study: Human Lung HIV-TB Co-infection ACE2+ Cells 18915 cells
This study contains the epithelial cells identified in a scRNA-seq dataset from lung tissue derived from surgical resection collected with Seq-Well S^3. We include for further investigation the epithelial subsets of the lung tissue which were the only subsets of cells in this dataset to express ACE2 and TMPRSS2. For all other cell subsets, we include only the expression of ACE2 and TMPRSS2.
Note that since this is a pre-publication dataset, we only include cell types which express ACE2 and metadata relevant to this inquiry. The full dataset will be released at a later date.
Note that this dataset was generated for a study unrelated to SARS-CoV-2 and no cells in this study were exposed to this virus.
Analysis of this data to evaluate expression of COVID-19 receptor ACE2 and protease TMPRSS2 are described in the following manuscript: https://www.cell.com/cell/fulltext/S0092-8674(20)30500-6
And summarized here: http://shaleklab.com/resource/covid-19-resources/
Contributors (listed alphabetically): Alasdair Leslie, Ian Mbano, Alex K. Shalek, Marc H. Wadsworth