Cells analyzed in the current work were isolated from a previously published swine influenza challenge study (85). Briefly, fourteen four-week-old commercial mixed breed pigs seronegative for antibodies against H1N1, H3N2, and B influenza viruses were intratracheally inoculated with 1 x 106 TCID50 2009 pandemic H1N1 A/California/04/2009 influenza virus, as previously described. Integrative analysis of lung and TBLN cells from combined FLU and FLU/OTV pigs at 5 dpi.