We perform a multi-modal characterisation of infiltrating lymphocytes in a RCC long term survivor to gain a greater understanding the biological basis of long-term survival. We developed a spatio-temporal map of B cell migration, which revealed extensive B and T cell activation and immunosurveillance across metastatic sites. We identified highly expanded immunosurveilling tumour-reactive B cell clones that interact directly with CD8 T cells resulting in activated T cell responses. We highlight multiple pathways by which anti-tumour immune responses may be generated and maintained over the 16 years of disease course.