This dataset corresponds to the integrated single-cell RNA sequencing (scRNA-seq) atlas shown in Figure 1A of the following study:

Kuwata Y, Yasuda K, Tsukita K et al."Characterizing Hypoxia-Orchestrated Post-Stroke Changes in Oligodendrocyte Precursor Cells for Improved Stroke Cell Therapy."

We constructed a harmonized atlas from publicly available 10x Genomics-based scRNA-seq datasets of the mouse brain after transient middle cerebral artery occlusion (tMCAO), covering multiple time points (sham, day 1, day 3, day 7, and day 14). After quality control and integration, the final dataset contains 106,905 cells.

The dataset includes the following major brain cell types, annotated based on marker gene expression and cross-referenced with Cell Ontology IDs for compatibility with SCP:

• B cells: CL_0000236 — B cell

• Choroid Plexus cells: CL_0000706 — choroid plexus epithelial cell

• Circulating Myeloid cells: CL_0000766 — myeloid leukocyte

• Endothelial cells: CL_0000115 — endothelial cell

• Ependymal cells: CL_0000065 — ependymal cell

• Fibroblasts: CL_0000057 — fibroblast

• Macrophages: CL_0000235 — macrophage

• Microglia: CL_0000129 — microglial cell

• Neural Progenitor cells: CL_0011020 — neural progenitor cell

• Neurons: CL_0000540 — neuron

• Oligodendrocytes: CL_0000128 — oligodendrocyte

• OPCs: CL_0002453 — oligodendrocyte precursor cell

• Pericytes: CL_0000669 — pericyte

• T cells and NK cells: CL_0000084 — T cell

• Neutrophils: CL_0000775 — neutrophil

Contact

For any questions or support, please contact kazusan@kuhp.kyoto-u.ac.jp .