Tissue Type(s): Olfactory Epithelium

Contributed by: Bradley J. Goldstein, Department of Head and Neck Surgery & Communication Sciences, Duke University Medical Center, Durham, NC, USA

Manuscript: Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells (https://www.biorxiv.org/content/10.1101/2020.04.19.049254v1)

Description: This study allows one to visualize and query genes as well as explore cell types, technical batches, and cell metrics associated with the manuscript. If published, this version of the data set is focused on the manuscript and is a subset of what may be made available by the original manuscript.

Original Publication: Durante, Michael A., et al. "Single-cell analysis of olfactory neurogenesis and differentiation in adult humans." Nature neuroscience 23.3 (2020): 323-326.

Full dataset: Sequencing data generated were deposited with the Gene Expression Omnibus with the accession code GSE139522, and relevant processed data is shared here in the downloads tab.

Abstract: The presence of active neurogenic niches in adult humans is controversial. We focused attention to the human olfactory neuroepithelium, an extracranial site supplying input to the olfactory bulbs of the brain. Using single-cell RNA sequencing analyzing 28,726 cells, we identified neural stem cell and neural progenitor cell pools and neurons. Additionally, we detailed the expression of 140 olfactory receptors. These data from the olfactory neuroepithelium niche provide evidence that neuron production may continue for decades in humans.