Tissue Type(s): Placenta

Contributed by: Thomas Tuschl, Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University, 1230 York Ave., Box 186, New York, NY 10065, USA, Zev Williams, Department of Obstetrics and Gynecology, Columbia University Medical Center, 630 W 168th St., New York, NY 10032, USA.

Manuscript: Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells (https://www.biorxiv.org/content/10.1101/2020.04.19.049254v1)

Description: This study allows one to visualize and query genes as well as explore cell types, technical batches, and cell metrics associated with the manuscript. If published, this version of the data set is focused on the manuscript and is a subset of what may be made available by the original manuscript.

Original Publication: Suryawanshi, Hemant, et al. "A single-cell survey of the human first-trimester placenta and decidua." Science Advances 4.10 (2018): eaau4788.

Full dataset: All data are available at https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA492324, and relevant processed data is shared here in the downloads tab.

Abstract: The placenta and decidua interact dynamically to enable embryonic and fetal development. Here, we report single-cell RNA sequencing of 14,341 and 6754 cells from first-trimester human placental villous and decidual tissues, respectively. Bioinformatic analysis identified major cell types, many known and some subtypes previously unknown in placental villi and decidual context. Further detailed analysis revealed proliferating subpopulations, enrichment of cell type–specific transcription factors, and putative intercellular communication in the fetomaternal microenvironment. This study provides a blueprint to further the understanding of the roles of these cells in the placenta and decidua for maintenance of early gestation as well as pathogenesis in pregnancy-related disorders.